Deep Brain Stimulation

A temporal interference stimulation excites an area in the mouse hippocampus, shown in bright green through c-fos labeling. Credit: Nir Grossman, Ph.D., Suhasa B. Kodandaramaiah, Ph.D., and Andrii Rudenko, Ph.D.

It is well known that electrical fields affect the working of the brain, by interfering with the electrical fields generated by the neurones. Scientists have proved over and over that stimulating specific area of the brain leads to a change in the behaviour. Advances have been made in deep brain stimulation to control epilepsy, as an example.

The problem with electrical stimulation of the brain is that it is very difficult to deliver the stimulation to exactly the target area without affecting nearby area with undesirable effects.  So far the approach has been to insert electrodes, through intracranial surgery, to bring the signal right to the area where stimulation has to take place.

This procedure is not satisfactory for at least three reasons: first it requires surgery with potential risk of damaging nearby neurones when inserting the electrode, second there may be infections deriving from the procedure and third the brain is a dynamic system, hence the stimulation may no longer be effective after a while since the brain in the meantime has changed its topology.

Now researchers at the MIT in cooperation with Beth’s Israel Deaconess Medical Centre and the IT’IS Foundation have found an alternative solution: generating electrical signals and having them interfering at the right place in the brain to affect its electrical activity.

The method is not invasive, all that is required is to place a few electrodes on the scalp. By finely tuning the electrical signals emitted by these electrodes through a computer (and changing the frequency, intensity and position of the electrodes)  it is possible to create an electrical stimulation in the deep brain to affect the target area. Each individual signal is too weak to affect the brain tissue it flows through, but at the target point all signals converge and interfere creating an electrical field that has the right power to interact with the local neuronal electrical field.

Deep brain stimulation is being used to control epilepsy, obsessive compulsive disorders, depression. Lately is also being experimented to treat conditions like autisms, although it is too early to derive conclusions on its effectiveness. Clearly, the possibility of performing deep brain stimulation through a non invasive procedures allows much better experimentations and researchers hope that this technique will allow faster progress in treating these and other brain pathologies, including Parkinson disease.

About Roberto Saracco

Roberto Saracco fell in love with technology and its implications long time ago. His background is in math and computer science. Until April 2017 he led the EIT Digital Italian Node and then was head of the Industrial Doctoral School of EIT Digital up to September 2018. Previously, up to December 2011 he was the Director of the Telecom Italia Future Centre in Venice, looking at the interplay of technology evolution, economics and society. At the turn of the century he led a World Bank-Infodev project to stimulate entrepreneurship in Latin America. He is a senior member of IEEE where he leads the New Initiative Committee and co-chairs the Digital Reality Initiative. He is a member of the IEEE in 2050 Ad Hoc Committee. He teaches a Master course on Technology Forecasting and Market impact at the University of Trento. He has published over 100 papers in journals and magazines and 14 books.