Tuesday September 16, 2014
Noon – 1 pm
Texas Instruments (TI) Auditorium E-1
2900 Semiconductor Drive
Santa Clara, CA
TITLE: Nanogel star polymers as interesting soft colloid materials for biomedical applications
SPEAKERS: Dr. Robert D. Miller, IBM Almaden Research Center
Polymers have numerous biomedical applications including delivery of therapeutic materials, imaging applications, tissue regeneration, antimicrobial action and others. We have developed a route to nanogel core star polymer amphiphiles with control over size, functionality, end groups and molecular architecture. These particles can either be biostable or biodegradable depending on the desired application. These materials encapsulate hydrophobic materials such as dyes at the 10-15% level without covalent bonding. The outer shell also sequesters magnetic particles for MRI studies and ligates ions such as copper 64 for PET. The outer shell can also be used to generate a functional silica shell or catalyze the electroless deposition of a gold shell. The later leads to a surface plasmon resonance absorption shifted into the near IR suitable for inducing hyperthermic processes in cells upon irradiation. We have also studied the antimicrobial properties of suitable substituted nanogel star polymers derivatives.
Robert D. Miller received his PhD in Organic Chemistry from Cornell University. He joined IBM at the T.J. Watson Research Laboratories in Yorktown Heights NY after his postdoctoral year and moved to the San Jose Research laboratory in 1972. He currently manages the Advanced Organic Materials Department at the IBM Almaden Research Laboratory.His research activities have included a wide range of technologies from: basic photochemical processes and mechanisms, radiation sensitive polymers and microlithography, controlled polymerization techniques, to nanoporous thin films for Bioscience, Optics and Photonics, photovoltaic materials and structures, sublithographic self assembly using block copolymers, air bridge dielectrics, radiation definable dielectrics, solution and CVD precursors for low-k applications, and others.
He is a member of the American Chemical Society and the Materials Research Society and currently serves on the editorial advisory boards of Chemical Reviews and Advanced Functional Materials. During his career, he has received five IBM awards for outstanding technical achievements, 31 invention plateau awards and is a member of the IBM Academy of Technology. Dr Miller was elected a Fellow of the Division of Polymeric Materials Science and Engineering (PMSE) in 2006 , the Materials Research Society (MRS) in 2007 and the American Chemical Society in 2011. In 2009, he was elected to the National Academy of Engineering and is the recipient of the 2010 American Chemical Society award for Chemistry of Materials Dr. Miller is a co-inventor on more than 70 patents and patent publications and has published more than 350 articles in refereed technical journals.
- 11:30 am – Registration & light lunch (pizza & drinks)
- Noon – Presentation & Questions/Answers
- 1:00 pm – Adjourn